Autosomal dominant disorder of platelet aggregation
Due to abnormally low levels of Von Willebrand's factor (protein modulating platelet adhesion) and/or qualitative issues impairing VFW factor function
Acquired VwD less common and is associated with processes that disrupt Vw Factor function: mechanical forces (abnormal valves, VSDs, LVADs, other), meds (e.g. cipro, valproate), malignancies (myeloma, mugs, myeloproliferative d/o), metabolic disorders (hypothyroidism), other

Variable severity and age of presentation based on amount of Von Willebrand's factor produced
Spontaneous mucocutanous bleeding → gums, nosebleeds
GI bleeding from angiodysplasia (higher shear forces in these vessels unmasks the disease)
Excessive bleeding during/after surgical procedures, minor trauma, dental extraction
Hematomas and occasionally intra-articular bleeding w/severe disease
In women, menorrhagia a common presenting symptom

Direct measurement of VWF
Assays to assess platelet function can be helpful if VFW levels indeterminate and/or clinical events w/adequate levels
Also Factor VIII levels, as it's related to VFW function

Von Willebrand Disease (hereditary Platelet Dysfxn)